• GSH - A new link between innate immune memory and immune regulation?

    GSH - A new link between innate immune memory and immune regulation?

    Added on 15 juli 2021
    This July, members of the INTRIM consortium published a beautiful study in Immunity. In this study, Matarese et al. show that the amino acid transporter which is responsible for the generation of GSH (SLC7A11) is crucial in the pathogenesis of Multiple Sclerosis by regulating the proliferation of Tregs. Since GSH was previously described in the context of trained immunity, could this be the link between trained immunity and the generation of immune regulation?
  • caloric restriction Cell Metabolism

    Eat less, stay healthy?

    Added on 4 februari 2021
    New research in Cell Metabolism from INTRIM members Giuseppe Matarese et al shows that (healthy) caloric restriction can promote trained immunity and protect from pulmonary MTB infection.
  • European Union ERC grant

    Protect independent research in the EU

    Added on 14 september 2020
    The EU is cutting ERC budgets, threatening independent research in the European Union. Researchers now call for protecting the budget and signing a petition. Read more here.
  • BCG vaccination against COVID19?

    BCG vaccination against COVID19?

    Added on 27 maart 2020
    Several members of the INTRIM consortium have started a clinical trial to test whether BCG vaccination can boost the human immune system, allowing it to better fight the virus that causes COVID19 and, perhaps, prevent infection with it altogether
  • 4th International Conference on Innate Immune Memory again a success!

    4th International Conference on Innate Immune Memory again a success!

    Added on 19 november 2019
    On 31 October and 1 November 2019, over 200 participants from a total of 20 countries gathered together in Nijmegen, The Netherlands, for the 4th International conference on Innate Immune Memory, which was organized by the department of Internal Medicine of the Radboud university medical centre. 77 abstracts from both early career researchers as well as senior scientists, among them many members of the INTRIM consortium, were submitted and the 2-day program was diverse and very interesting.
  • Professorship opening on Inflammation and Hematopoiesis in Dresden

    Professorship opening on Inflammation and Hematopoiesis in Dresden

    Added on 2 oktober 2019
    The Carl Gustav Carus Faculty of Medicine and the University Hospital Carl Gustav Carus of the
    Technische Universität Dresden are offering a professorshop position at earliest convenience as a
    Chair (W2) of Inflammation and Hematopoiesis. Please click on the title for the ad and more information.
  • 'New Frontiers in Innate Immune Memory' in Nijmegen, 31 Oct - 1 November 2019

    'New Frontiers in Innate Immune Memory' in Nijmegen, 31 Oct - 1 November 2019

    Added on 8 februari 2019
    The Radboud university medical center for Infectious Diseases invites you on October 31 and November 1st to the international symposium ‘New Frontiers in Innate Immune Memory’ in the city of Nijmegen, the Netherlands.

    This international symposium will cover novel aspects on innate immune memory, starting from evolutionary aspects, to molecular mechanisms, and translational aspects important for infections, vaccination, inflammatory diseases and cancer. An international group of experts in the field will present their work, including Kenneth Walsh, Michael Skinner, Joachim Schultze, Maria-Carla Saleh, Joseph Sun, Triantafyllos Chavakis, Keiko Ozato, Maziar Divangahi, Mihai Netea, Robin Choudhury, Luis Barreiro, Musa Mhlanga, Ramnik Xavier, Christine Stabell-Benn, Nigel Curtis, Willem Mulder.
  • New Frontiers in Innate Immunity and Inflammation 2018 a great success

    New Frontiers in Innate Immunity and Inflammation 2018 a great success

    Added on 22 oktober 2018
    From the 5th to the 7th of September 2018, the ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, the Romanian Center for Systems Immunology, and Radboud Center for Infectious Diseases Nijmegen joined forces to organize the ‘New Frontiers in Innate Immunity and Inflammation’ meeting. Read all about it here!
  • Researchers of the INTRIM consortium publish 4 papers in Cell

    Researchers of the INTRIM consortium publish 4 papers in Cell

    Added on 15 januari 2018
    The immune system not only detects and destroys pathogens such as microbes but also plays a role in the onset of diseases such as arteriosclerosis. Scientists from Radboud university medical center, together with fellow scientists from Bonn, Dresden and Pennsylvania, studied a new mechanism that regulates the immune system’s functioning. For example, they discovered that cholesterol inhibitors may prevent infections, that a high-fat Western diet can have a long-lasting effect on our immunity and that even our stem cells can be disrupted. Today, four publications on the manipulation of our immune system appear in Cell and Cell Host & Microbe (three articles in Cell, one article in Cell Host & Microbe).
  • The innate immune system can also be trained

    The innate immune system can also be trained

    Added on 15 januari 2018
    “Training” of precursors of white blood cells leads to a sustained positive response of the hematopoietic system. This effect could help accelerate the formation of new white blood cells, which are vitally needed during chemotherapy, a process that can slow down hematopoiesis. In a publication that appeared in the prestigious journal Cell, the scientists Dr. Ioannis Mitroulis and Prof. Triantafyllos Chavakis of the Institute of Clinical Chemistry and Laboratory Medicine of the University Hospital Carl Gustav Carus at the TU Dresden together with international colleagues describe this groundbreaking training effect on the innate immune system, which could be exploited therapeutically to prevent specific side effects of chemotherapy.
  • Fast food makes the immune system more aggressive in the long term

    Fast food makes the immune system more aggressive in the long term

    Added on 15 januari 2018
    The immune system reacts similarly to a high fat and high calorie diet as to a bacterial infection. This is shown by a recent study led by the University of Bonn. Particularly disturbing: Unhealthy food seems to make the body’s defenses more aggressive in the long term. Even long after switching to a healthy diet, inflammation towards innate immune stimulation is more pronounced. These long-term changes may be involved in the development of arteriosclerosis and diabetes, diseases linked to Western diet consumption. The results will be published in the journal ‘Cell’.
  • International symposium 'New Frontiers in Innate Immunity and Inflammation'

    International symposium 'New Frontiers in Innate Immunity and Inflammation'

    Added on 22 oktober 2017
    The ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, the Romanian Center for Systems Immunology, and Radboud Center for Infectious Diseases Nijmegen invites you on Sept. 5th-7th 2018 to the international symposium ‘New Frontiers in Innate Immunity and Inflammation’ in the city of Cluj-Napoca, the heart of Transylvania.
  • The 3rd Innate Immune Memory Wellcome Trust conference

    The 3rd Innate Immune Memory Wellcome Trust conference

    Added on 4 oktober 2017
    The 3rd Innate Immune Memory Wellcome Trust conference will take place in Cambridge, UK, in March 2019. The conference will focus on cutting edge research understanding of the adaptive features of the innate immune system and how it can be activated and regulated.